Public Health England has published The wellbeing of 15-year-olds: further analysis of the 2014 What About YOUth survey. This report highlights associations between health behaviours, other self-rated life factors (such as bullying and body image) and wellbeing in 15 year olds. The report is intended to help commissioners and providers of health, social care and education to target resources where they are likely to have most impact in improving the wellbeing of young people.
The baseline assessment tool for NG61 was applied to our own organisation (Helen & Douglas House), as well as to partner organisations within Thames Valley Paediatric Palliative Care Network, comprising NHS services and third sector charities.
We identified areas for improvement specific to our own service, as well as those that would be best tackled as a regional network (either by the use of referral pathways or joint working on developing written resources for patients). We were able to demonstrate improved compliance between the assessments at Helen & Douglas House conducted in March 2017 and October 2017 (from 84% to 90%).
We now plan to use our learning to support other organisations in the region to adapt their own internal processes by sharing examples of good practice, such as care plans, symptom assessment tools and referral pathways. Our data has also been submitted to Together for Short Lives, who are mapping a national picture of the baseline assessment outcomes for NG61.
Tonic-clonic convulsions and convulsive status epilepticus (currently defined as a tonic-clonic convulsion lasting at least 30 minutes) are medical emergencies and require urgent and appropriate anticonvulsant treatment. International consensus is that an anticonvulsant drug should be administered for any tonic-clonic convulsion that has been continuing for at least five minutes. Benzodiazepines (diazepam, lorazepam, midazolam) are traditionally regarded as first-line drugs and phenobarbital, phenytoin and paraldehyde as second-line drugs.
This is an update of a Cochrane Review first published in 2002 and updated in 2008.
We have not identified any new high-quality evidence on the efficacy or safety of an anticonvulsant in stopping an acute tonic-clonic convulsion that would inform clinical practice. There appears to be a very low risk of adverse events, specifically respiratory depression. Intravenous lorazepam and diazepam appear to be associated with similar rates of seizure cessation and respiratory depression. Although intravenous lorazepam and intravenous diazepam lead to more rapid seizure cessation, the time taken to obtain intravenous access may undermine this effect. In the absence of intravenous access, buccal midazolam or rectal diazepam are therefore acceptable first-line anticonvulsants for the treatment of an acute tonic-clonic convulsion that has lasted at least five minutes. There is no evidence provided by this review to support the use of intranasal midazolam or lorazepam as alternatives to buccal midazolam or rectal diazepam.
Question Can anti–vascular endothelial growth factor (VEGF) therapy in retinopathy of prematurity (ROP) be improved by using ranibizumab given at lower doses than the standard treatment, bevacizumab, thus alleviating systemic safety concerns while effectively treating disease?
Findings In this randomized clinical trial with 20 patients, both investigated ranibizumab doses were lower than the current standard bevacizumab dose for ROP. Both ranibizumab doses were effective in controlling acute ROP (17 of 18 per protocol treated eyes [94%] with 0.12 mg and 13 of 14 per protocol treated eyes [93%] with 0.20 mg); systemic VEGF levels remained unchanged.
Meaning Low-dose ranibizumab is effective in treating acute ROP without suppressing plasma VEGF levels.
The technology described in this briefing is a next-generation sequencing (NGS)-based panel, used to sequence genetic mutations in solid tumour cancers in children.
The innovative aspects are that it was developed with input from a wide range of experts, so it is highly optimised and tailored specifically to solid tumours in children.
The intended place in therapy would be in addition to standard care, or as a replacement to less extensive gene testing, to expand the level of genomic analysis in children with solid tumour cancers.
The main points from the evidence summarised in this briefing are from 1 UK analytical validity and diagnostic accuracy study that included a total of 132 samples, in a genomics laboratory, using clinical samples from laboratories worldwide. This showed that the NGS panel detected 94 of 95 (98.9%) well-characterised genetic abnormalities in 33 clinical specimens and 13 cell lines.
Key uncertainties around the evidence or technology are that the technology is still in early development, so the evidence base is not fully established. Further evidence generation is planned and in progress.
The cost of the NGS panel varies according to sample throughput, but is estimated to be £346 to £651 per patient (excluding VAT). The resource impact would be initially cost-incurring, but using the NGS panel could lead to the development of targeted therapies using biological agents or targeted drugs for cancer in children.
Link to full briefing here
Background: Children and young people with long-term conditions are not always provided with opportunities to engage fully in consultations. This systematic review examined the effectiveness or worth of methods used to engage children and young people with long-term conditions in their consultations. Conclusions: This review has demonstrated that interventions targeted at children and young people with long-term conditions can improve their levels of engagement in consultations. There is a need for more systematic development and robust evaluation of interventions to improve children’s active participation in consultations.