JAMA Paediatrics: Comparison of Antibiotic Therapy and Appendectomy for Acute Uncomplicated Appendicitis in Children

 

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Question  Are antibiotics as initial treatment appropriate for uncomplicated acute appendicitis in pediatric patients?

Findings  In this meta-analysis of 5 studies (including 404 patients), antibiotic treatment was safe and effective in 152 of 168 pediatric patients (90.5%), but the risk for treatment failure increased significantly in patients with appendicolith.

Meaning  Antibiotic treatment can be used as primary treatment in pediatric patients presenting with acute uncomplicated appendicitis without appendicolith.

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