Severe sialorrhoea (drooling) in children and young people with chronic neurological disorders: oral glycopyrronium bromide

NICE Evidence Summary, February 2017

Glycopyrronium bromide (Sialanar) is an antimuscarinic (anticholinergic) medicine licensed in September 2016 for the symptomatic treatment of severe sialorrhoea (chronic pathological drooling) in children and adolescents aged 3 years and older with chronic neurological disorders. Sialanar is licensed for short-term intermittent use and is only licensed in children. There is limited clinical trial evidence on the use of glycopyrronium in adults with sialorrhoea. Sialanar 320 micrograms/ml oral solution is the first formulation of glycopyrronium bromide licensed for this indication in the UK.

Link to NICE Evidence Summary


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